Rabies

Rabies PDF
Author: William H. Wunner
Publisher: Academic Press
ISBN: 9780080550091
Size: 49.69 MB
Format: PDF, ePub, Docs
Category : Science
Languages : en
Pages : 680
View: 682

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Rabies is the most current and comprehensive account of one of the oldest diseases known that remains a significant public health threat despite the efforts of many who have endeavored to control it in wildlife and domestic animals. During the past five years since publication of the first edition there have been new developments in many areas on the rabies landscape. This edition takes on a more global perspective with many new authors offering fresh outlooks on each topic. Clinical features of rabies in humans and animals are discussed as well as basic science aspects, molecular biology, pathology, and pathogenesis of this disease. Current methods used in defining geographic origins and animal species infected in wildlife are presented, along with diagnostic methods for identifying the strain of virus based on its genomic sequence and antigenic structure. This multidisciplinary account is essential for clinicians as well as public health advisors, epidemiologists, wildlife biologists, and research scientists wanting to know more about the virus and the disease it causes. * Offers a unique global perspective on rabies where dog rabies is responsible for killing more people than yellow fever, dengue fever, or Japanese encephalitis * More than 7 million people are potentially exposed to the virus annually and about 50,000 people, half of them children, die of rabies each year * New edition includes greatly expanded coverage of bat rabies which is now the most prominent source of human rabies in the New World and Western Europe, where dog rabies has been controlled * Recent successes of controlling wildlife rabies with an emphasis on prevention is discussed * Approximately 40% updated material incorporates recent knowledge on new approaches to therapy of human rabies as well as issues involving organ and tissue transplantation * Includes an increase in illustrations to more accurately represent this diseases’ unique horror

Rabies

Rabies PDF
Author: Anthony R. Fooks
Publisher: Academic Press
ISBN: 0128205725
Size: 55.42 MB
Format: PDF, ePub, Docs
Category : Medical
Languages : en
Pages : 732
View: 4325

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Rabies: Basis of the Disease and Its Management, Fourth Edition is an authoritative reference on the current status of rabies, including the virological, clinical, and public health aspects and management recommendations. Rabies remains one of the most important global public health problems worldwide. Although many important developments have been made over the past century to combat this disease, rabies has become a re-emergent infection in the resource-constrained countries. The Fourth Edition updates this classic reference with comprehensive coverage of the molecular virology, pathogenesis, immunology, vaccines, public health aspects, and epidemiology of rabies and is completely revised, with new chapters that will cover historical developments in rabies intervention strategies, the evolution of rabies virus, modeling rabies control, and on the strategy for rabies elimination. Rabies, Fourth Edition, provides physicians, veterinarians, public health advisors, epidemiologists, and research scientists with a single source for authoritative and up-to-date information on the diagnosis, treatment, control, and prevention of this fatal infectious virus. Edited by renowned researchers in this subject and has gathered a team of experts to detail the science, treatment, and control of rabies Completely revised, the Fourth Edition presents rabies as a re-emergent infection with emphasis on a global perspective of the disease Includes new chapters the evolution of the rabies virus and on modeling rabies control and includes many full-color figures that highlight important information

Rabies In The Tropics

Rabies in the Tropics PDF
Author: E. Kuwert
Publisher: Springer Science & Business Media
ISBN: 3642700608
Size: 71.93 MB
Format: PDF, Docs
Category : Medical
Languages : en
Pages : 786
View: 2626

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Rabies-as in former times-is still today a major killer affecting man and animals especially in many tropical and sub-tropical countries of Asia, Africa and South America. Some 50,000 people and literally millions of animals suffer and die of this disease each year. This dramatic death toll and the enormous economic losses which ensue are nowadays un tolerable and no longer justified. Worldwide strategy for Rabies control has been established and the World Health Organization recently formulated an elimination programme for dog Rabies. Methods for wildlife Rabies control are also under way. For the realisation of control campaigns, careful epid emiological analysis is necessary. This involves: - antigenical characterisation of Rabies Virus Strains using monoclonal antibodies, - observation of foci, - follow-up of the front wave of the disease, - specific ecology of target populations and Rabies carrier species. The financial point of view of such campaigns has of course to be ascertained. It is for the first time ever that representatives and specialists of different biological disciplines from nearly 70 countries have had the opportunity in Tunis to discuss these important issues and to evaluate, on the basis of their own experimental results and personal epidemiological observations, the possibility of ultimate elimination of Rabies in tropical and sub-tropical countries and also to contribute their share for a better understanding of the natural history of this disease.

Who Expert Consultation On Rabies

WHO Expert Consultation on Rabies PDF
Author: World Health Organization
Publisher: World Health Organization
ISBN: 9241209313
Size: 13.64 MB
Format: PDF, Kindle
Category : Medical
Languages : en
Pages : 88
View: 6833

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More than 99% of all human rabies deaths occur in the developing world and although effective and economical control measures are available the disease has not been brought under control throughout most of the affected countries. Given that a major factor in the low level of commitment to rabies control is a lack of accurate data on the true public health impact of the disease this report of a WHO Expert Consultation begins by providing new data on the estimated burden of the disease and its distribution in the world. It also reviews recent progress in the classification of rabies viruses rabies pathogenesis and diagnosis rabies pre- and post-exposure prophylaxis the management of rabies patients and canine as well as wildlife rabies prevention and control.

Historical Perspective Of Rabies In Europe And The Mediterranean Basin

Historical Perspective of Rabies in Europe and the Mediterranean Basin PDF
Author: Arthur A. King
Publisher: World Organization for Animal
ISBN:
Size: 53.63 MB
Format: PDF, ePub
Category : Medical
Languages : en
Pages : 361
View: 4180

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Aim of this book is to provide scientists, veterinarians and policy-makers with an expert analysis of rabies from ancient times to today. The principle objectives are to summarise our knowledge of the history of rabies in Europe and the Mediterranean Basin and to describe the various strategies that have been used to eliminate (terrestrial) rabies from reservoir populations.

Rabies Virus Infektion Der Maus Einfluss Des Viralen Glykoproteins Auf Die Immunantwort Im Zns

Rabies Virus Infektion der Maus  Einfluss des viralen Glykoproteins auf die Immunantwort im ZNS  PDF
Author:
Publisher:
ISBN:
Size: 27.42 MB
Format: PDF, ePub, Docs
Category :
Languages : de
Pages :
View: 4789

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Das Glykoprotein des Rabies-Virus (RV-G) spielt durch die Beeinflussung der Neuroinvasivität und durch die Modulation antiviraler Immunreaktionen eine zentrale Rolle bei der Rabies-Virus-Erkrankung (Tollwut). Bisher ist noch nicht bekannt, durch welchen Mechanismus RV-G die Pathogenität des Virus beeinflusst, wenn dieses das ZNS erreicht hat. Um Die Bedeutung der RV-G-Expression im ZNS zu untersuchen, infizierten wir Mäuse intranasal mit attenuierten Rabies-Viren des Stammes SPBN sowie mit Viren des Stammes SPBN-DOG4; dieser Stamm unterscheidet sich von SPBN insofern, als dass die für RV-G kodierende Gensequenz gegen die des hoch pathogenen Wildtyp-Stammes DOG4 ersetzt worden ist. Bei intramuskulärer Inokulation von SPBN überlebten alle der infizierten Mäuse, bei SPBN-DOG4 führte dies zu einer Mortalitätsrate von 30%. Bei intranasaler Inokulation hingegen führte die Infektion zu einer jeweiligen Mortalitätsrate von 100%. Die mittlere Überlebenszeit war dabei in der SPBN-Gruppe signifikant gegenüber der SPBN-DOG4-Gruppe erniedrigt, was aufgrund der beschleunigten Krankheitsprogression auf eine erhöhte Pathogenität von SPBN hinweist. Bei den mit SPBN infizierten Tieren fand sich zudem ein erniedrigter Spiegel von IL-6, von Virusneutralisierenden Antikörpern sowie eine verminderte Glia-Aktivierung. Diese verminderten immunologischen Abwehrreaktionen korrelierten mit einem verminderten Virus-Titer und einer verminderten globalen RV-G- und Ribonukleoprotein-Expression im gesamten ZNS. Bei der Quantifizierung der Virusmenge in einzelnen Neuronen konnte jedoch festgestellt werden, dass die zelluläre RV-G-Expression in der SPBN-Gruppe signifikant erhöht war. Dieser neue Befund zeigt klar, dass die zellulären Expressionspiegel und weniger die globale Viruslast im Gehirn wesentlich zu der Pathogenität des Rabies-Virus beitragen. Aufgrund dieser Daten könnte die Entwicklung von Behandlungsschemata, die zu einer Blockade der Expression von RV-G in einzelnen Neuronen führen, ein.

No One Should Die Of Rabies

No One Should Die of Rabies PDF
Author: Dr. Ashok Banga
Publisher: Notion Press
ISBN: 1638735468
Size: 67.38 MB
Format: PDF, Kindle
Category : Medical
Languages : en
Pages : 166
View: 3729

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This book is about the victory of science, and yet, the failure of our system to deliver its benefits to the needy, causing more than 55,000 deaths year after year due to rabies. Why should someone die of rabies when we have all the means to protect each life? Why do developing countries still suffer when developed countries have largely eliminated the disease? Although rabies is incurable, and once contracted equals to a death sentence, it can be effectively prevented with an inexpensive vaccine. These questions, and many more, haunt those whose loved ones are exposed to rabies and yet cannot find clear answers, leading to panic and anxiety. Even medical professionals are not well versed with latest recommendations and methods for dealing with each patient’s unique condition. The abundance of half-baked and misleading information causes further confusion and mismanagement in a time when urgency is crucial. Each rabies death is a failure of our knowledge-sharing and health-care systems. This book contains easy access to medically correct, evidence-based information to aid both doctors and patients in informed decision-making. The author, a doctor and a top writer on Quora – the popular knowledge sharing platform – has made the whole subject easy to understand and interesting to read, with to-the-point answers and without academic jugglery.

Rabies

Rabies PDF
Author: California. Bureau of Communicable Diseases. Veterinary Public Health Section
Publisher:
ISBN:
Size: 19.13 MB
Format: PDF, Kindle
Category :
Languages : en
Pages :
View: 1258

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Rabies

Rabies PDF
Author: David Sime
Publisher: Cambridge University Press
ISBN: 1107456606
Size: 60.11 MB
Format: PDF, Docs
Category : Medical
Languages : en
Pages : 306
View: 5421

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First published in 1903, this book presents a wide-ranging study of rabies. Three key areas of the disease are explored: its causation in the individual organism, its place among germ diseases with the end of bacterial agency in the animal economy, and its origin in the animal kingdom. This book will be of value to anyone with an interest in epidemiology and the historical understanding of rabies.

Rabies

Rabies PDF
Author: G. N. Henderson
Publisher: Random House Business
ISBN:
Size: 67.91 MB
Format: PDF, Docs
Category : Rabies
Languages : en
Pages : 145
View: 6357

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Rabies

Rabies PDF
Author: James Campbell
Publisher: Springer
ISBN: 9781461289852
Size: 36.75 MB
Format: PDF
Category : Medical
Languages : en
Pages : 434
View: 4851

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Rabies is an ancient disease and a fearsome one. Although it may not have the economic or public health importance of some other infectious diseases, few are so well known or carry the same emotional impact. Mainly transmitted by the bite of an enraged animal, and with practically no hope for recovery among those afflicted, it has provided the substance of stories and legends throughout the ages. The pioneering work of many 19th century workers, culminating in the development of the first rabies vaccines by Louis Pasteur, provided the ground work for the modern era in the study of rabies. Since then, and particularly in the last quarter century, considerable advances have been made in our knowledge of the nature of the infectious agent, its mode of transmission and pathogenetic mechanisms. Yet even today, much remains to be learned about the disease. For example, although effective vaccines exist for humans and other animals, there is still no known practical cure once the neurological disease symptoms develop. Markers of virulence have been mapped at the molecular level, but it is yet unclear as to how rabies virus actually exerts its pathological effects.

The Natural History Of Rabies

The Natural History of Rabies PDF
Author: George M. Baer
Publisher: Routledge
ISBN: 1351409794
Size: 52.82 MB
Format: PDF, Mobi
Category : Medical
Languages : en
Pages : 640
View: 7343

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This book provides essential worldwide reference information regarding rabies for public health officials, veterinarians, physicians, virologists, epidemiologists, infectious disease specialists, laboratory diagnosticians, and wildlife biologists. The book is divided into six main sections, covering topics such as the rabies virus, including antigenic and biochemical characteristics; pathogenesis, including the immune response to the infection, pathology, and latency; diagnostic techniques; rabies epidemiology in a variety of wild and domestic animals; rabies control, including vaccination of wild and domestic animals, as well as control on the international level; and finally a discussion of rabies in humans, local wound and serum treatment, and human post-exposure vaccination. Natural History of Rabies, First Edition has been the principal worldwide reference since 1975. The new Second Edition has been completely updated, providing current information on this historically deadly disease.