Natural Product Biosynthesis

Natural Product Biosynthesis PDF
Author: Christopher T. Walsh
Publisher: Royal Society of Chemistry
ISBN: 1788010760
Size: 47.71 MB
Format: PDF, ePub
Category : Enzymology
Languages : en
Pages : 765
View: 6079

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This textbook describes the types of natural products, the biosynthetic pathways that enable the production of these molecules, and an update on the discovery of novel products in the post-genomic era.

Natural Product Biosynthesis By Microorganisms And Plants

Natural Product Biosynthesis by Microorganisms and Plants PDF
Author: David A. Hopwood
Publisher: Academic Press
ISBN: 0123942918
Size: 54.77 MB
Format: PDF, ePub, Mobi
Category : Medical
Languages : en
Pages : 393
View: 3260

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This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. The second of 3 volumes covering Natural product biosynthesis by microorganisms and plants. This new volume continues the legacy of this premier serial Contains quality chapters authored by leaders in the field The second of 3 volumes it has chapters on such topics as biological chlorination, bromination and iodination, and phylogenetic approaches to natural product structure prediction

Medicinal Natural Products

Medicinal Natural Products PDF
Author: Paul M. Dewick
Publisher: Wiley
ISBN: 9780470741672
Size: 36.95 MB
Format: PDF
Category : Science
Languages : en
Pages : 550
View: 5053

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Medicinal Natural Products: A Biosynthetic Approach, Third Edition, provides a comprehensive and balanced introduction to natural products from a biosynthetic perspective, focussing on the metabolic sequences leading to various classes of natural products. The book builds upon fundamental chemical principles and guides the reader through a wealth of diverse natural metabolites with particular emphasis on those used in medicine. There have been rapid advances in biosynthetic understanding over the past decade through enzymology, gene isolation and genetic engineering. Medicinal Natural Products has been extended and fully updated in this new edition to reflect and explain these developments and other advances in the field. It retains the user-friendly style and highly acclaimed features of previous editions: a comprehensive treatment of plant, microbial, and animal natural products in one volume extensive use of chemical schemes with annotated mechanistic explanations cross-referencing to emphasize links and similarities boxed topics giving further details of medicinal materials, covering sources, production methods, use as drugs, semi-synthetic derivatives and synthetic analogues, and modes of action Medicinal Natural Products: A Biosynthetic Approach, Third Edition, is an invaluable textbook for students of pharmacy, pharmacognosy, medicinal chemistry, biochemistry and natural products chemistry.

Natural Product Synthesis I

Natural Product Synthesis I PDF
Author: Johann H. Mulzer
Publisher: Springer
ISBN: 9783642059339
Size: 46.91 MB
Format: PDF, ePub, Mobi
Category : Science
Languages : en
Pages : 239
View: 4941

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Natural Products

Natural Products PDF
Author: Anne Osbourn
Publisher: John Wiley & Sons
ISBN: 1118794605
Size: 55.71 MB
Format: PDF, Mobi
Category : Science
Languages : en
Pages : 552
View: 2713

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Natural Products: Discourse, Diversity andDesign provides an informative and accessible overview ofdiscoveries in the area of natural products in the genomic era,bringing together advances across the kingdoms. As genomicsdata makes it increasingly clear that the genomes of microbes andplants contain far more genes for natural product synthesis thanhad been predicted from the numbers of previously identifiedmetabolites, the potential of these organisms to synthesize diversenatural products is likely to be far greater than previouslyenvisaged. Natural Products addresses notonly the philosophical questions of the natural role of thesemetabolites, but also the evolution of single and multiplepathways, and how these pathways and products may be harnessed toaid discovery of new bioactives and modes of action. Edited by recognized leaders in the fields of plant andmicrobial biology, bioorganic chemistry and natural productschemistry, and with contributions from researchers at top labsaround the world, Natural Products isunprecedented in its combination of disciplines and the breadth ofits coverage. Natural Produces: Discourse, Diversity andDesign will appeal to advanced students andexperienced researchers, from academia to industry, in diverseareas including ecology, industrial biotechnology, drug discovery,medicinal chemistry, agronomy, crop improvement, and naturalproduct chemistry.

Chemistry Of Plant Natural Products

Chemistry of Plant Natural Products PDF
Author: Sunil Kumar Talapatra
Publisher: Springer
ISBN: 3642454100
Size: 30.87 MB
Format: PDF, Mobi
Category : Science
Languages : en
Pages : 1180
View: 3674

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Aimed at advanced undergraduate and graduate students and researchers working with natural products, Professors Sunil and Bani Talapatra provide a highly accessible compilation describing all aspects of plant natural products. Beginning with a general introduction to set the context, the authors then go on to carefully detail nomenclature, occurrence, isolation, detection, structure elucidation (by both degradation and spectroscopic techniques) stereochemistry, conformation, synthesis, biosynthesis, biological activity and commercial applications of the most important natural products of plant origin. Each chapter also includes detailed references (with titles) and a list of recommended books for additional study making this outstanding treatise a useful resource for teachers of chemistry and researchers working in universities, research institutes and industry.

Complex Enzymes In Microbial Natural Product Biosynthesis Part A Overview Articles And Peptides

Complex Enzymes in Microbial Natural Product Biosynthesis  Part A  Overview Articles and Peptides PDF
Author:
Publisher: Academic Press
ISBN: 0080923356
Size: 79.50 MB
Format: PDF, Docs
Category : Science
Languages : en
Pages : 350
View: 3513

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Microbial natural products have been an important traditional source of valuable antibiotics and other drugs but interest in them waned in the 1990s when big pharma decided that their discovery was no longer cost-effective and concentrated instead on synthetic chemistry as a source of novel compounds, often with disappointing results. Moreover understanding the biosynthesis of complex natural products was frustratingly difficult. With the development of molecular genetic methods to isolate and manipulate the complex microbial enzymes that make natural products, unexpected chemistry has been revealed and interest in the compounds has again flowered. This two-volume treatment of the subject will showcase the most important chemical classes of complex natural products: the peptides, made by the assembly of short chains of amino acid subunits, and the polyketides, assembled from the joining of small carboxylic acids such as acetate and malonate. In both classes, variation in sub-unit structure, number and chemical modification leads to an almost infinite variety of final structures, accounting for the huge importance of the compounds in nature and medicine. * Gathers tried and tested methods and techniques from top players in the field. * In depth coverage of ribosomally-synthesised and Non-ribosomally-synthesised peptides. * Provides an extremely useful reference for the experienced research scientist.

Chemistry Of Plant Natural Products

Chemistry of Plant Natural Products PDF
Author: Sunil Kumar Talapatra
Publisher: Springer
ISBN: 9783662519417
Size: 36.25 MB
Format: PDF, ePub, Mobi
Category : Science
Languages : en
Pages : 1180
View: 4436

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Aimed at advanced undergraduate and graduate students and researchers working with natural products, Professors Sunil and Bani Talapatra provide a highly accessible compilation describing all aspects of plant natural products. Beginning with a general introduction to set the context, the authors then go on to carefully detail nomenclature, occurrence, isolation, detection, structure elucidation (by both degradation and spectroscopic techniques) stereochemistry, conformation, synthesis, biosynthesis, biological activity and commercial applications of the most important natural products of plant origin. Each chapter also includes detailed references (with titles) and a list of recommended books for additional study making this outstanding treatise a useful resource for teachers of chemistry and researchers working in universities, research institutes and industry.

Natural Product Biosynthesis By Microorganisms And Plants

Natural Product Biosynthesis by Microorganisms and Plants PDF
Author:
Publisher: Academic Press
ISBN: 0123946271
Size: 21.34 MB
Format: PDF, ePub
Category : Science
Languages : en
Pages : 472
View: 832

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This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. The first of 3 volumes covering Natural product biosynthesis by microorganisms and plants, it has chapters on such topics as Kinetics of plant sesquiterpene synthases, Terpenoid biosynthesis in fungi, and plant Type III polyketide synthases. Contains quality chapters authored by leaders in the field The first of 3 volumes Has chapters on such topics as kinetics of plant sesquiterpene synthases, terpenoid biosynthesis in fungi, and plant Type III polyketide synthases

Natural Product Biosynthesis By Microorganisms And Plants

Natural Product Biosynthesis by Microorganisms and Plants PDF
Author:
Publisher: Academic Press
ISBN: 0124046177
Size: 56.20 MB
Format: PDF, Kindle
Category : Science
Languages : en
Pages : 512
View: 920

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This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. The third of 3 volumes covering Natural product biosynthesis by microorganisms and plants. This new volume continues the legacy of this premier serial Contains quality chapters authored by leaders in the field The third of 3 volumes, it has chapters on such topics as metabolic pathways in Aspergillus oryzae, heterologous gene clusters and cyanobacteria as a source of natural products

Asymmetric Synthesis Of Natural Products

Asymmetric Synthesis of Natural Products PDF
Author: Ari M. P. Koskinen
Publisher: John Wiley & Sons
ISBN: 1118347331
Size: 21.79 MB
Format: PDF, Docs
Category : Science
Languages : en
Pages : 328
View: 1264

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Asymmetric Synthesis of Natural Products, 2nd Edition introduces students to this rapidly growing field of organic chemistry. The initial chapters present the foundations of asymmetric synthesis, including the theory and applications of individual asymmetric reactions. This is followed by chapters on each of the major individual classes of natural products; their structures, biosynthesis and interrelationships as well as examples of asymmetric syntheses and the practical value of these compounds. Natural product classes covered include carbohydrates, amino acids, peptides, proteins, nucleosides, nucleotides, nucleic acids, polyketides, isoprenoids, shikamic acid derivatives and alkaloids. For this second edition the text has been thoroughly updated and expanded, and includes new discussions and examples covering atom and redox economies, practical aspects and environmental awareness. Organocatalysis has emerged completely in the last ten years, and has been fully integrated into this new edition.

Complex Enzymes In Microbial Natural Product Biosynthesis Part A Overview Articles And Peptides

Complex Enzymes in Microbial Natural Product Biosynthesis  Part A  Overview Articles and Peptides PDF
Author:
Publisher: Academic Press
ISBN: 9780123745880
Size: 49.87 MB
Format: PDF, ePub, Docs
Category : Science
Languages : en
Pages : 350
View: 4773

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Microbial natural products have been an important traditional source of valuable antibiotics and other drugs but interest in them waned in the 1990s when big pharma decided that their discovery was no longer cost-effective and concentrated instead on synthetic chemistry as a source of novel compounds, often with disappointing results. Moreover understanding the biosynthesis of complex natural products was frustratingly difficult. With the development of molecular genetic methods to isolate and manipulate the complex microbial enzymes that make natural products, unexpected chemistry has been revealed and interest in the compounds has again flowered. This two-volume treatment of the subject will showcase the most important chemical classes of complex natural products: the peptides, made by the assembly of short chains of amino acid subunits, and the polyketides, assembled from the joining of small carboxylic acids such as acetate and malonate. In both classes, variation in sub-unit structure, number and chemical modification leads to an almost infinite variety of final structures, accounting for the huge importance of the compounds in nature and medicine. * Gathers tried and tested methods and techniques from top players in the field. * In depth coverage of ribosomally-synthesised and Non-ribosomally-synthesised peptides. * Provides an extremely useful reference for the experienced research scientist.

Complex Enzymes In Microbial Natural Product Biosynthesis Part B Polyketides Aminocoumarins And Carbohydrates

Complex Enzymes in Microbial Natural Product Biosynthesis  Part B  Polyketides  Aminocoumarins and Carbohydrates PDF
Author:
Publisher: Academic Press
ISBN: 9780080923369
Size: 10.68 MB
Format: PDF
Category : Science
Languages : en
Pages : 398
View: 2052

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Microbial natural products have been an important traditional source of valuable antibiotics and other drugs but interest in them waned in the 1990s when big pharma decided that their discovery was no longer cost-effective and concentrated instead on synthetic chemistry as a source of novel compounds, often with disappointing results. Moreover understanding the biosynthesis of complex natural products was frustratingly difficult. With the development of molecular genetic methods to isolate and manipulate the complex microbial enzymes that make natural products, unexpected chemistry has been revealed and interest in the compounds has again flowered. This two-volume treatment of the subject will showcase the most important chemical classes of complex natural products: the peptides, made by the assembly of short chains of amino acid subunits, and the polyketides, assembled from the joining of small carboxylic acids such as acetate and malonate. In both classes, variation in sub-unit structure, number and chemical modification leads to an almost infinite variety of final structures, accounting for the huge importance of the compounds in nature and medicine. * Gathers tried and tested methods and techniques from top players in the field. * Provides an extremely useful reference for the experienced research scientist. * Covers biosynthesis of Polyketides, Tarpenoids, Aminocoumarins and Crabohydrates