Computational Systems Neurobiology

Computational Systems Neurobiology PDF
Author: N. Le Novère
Publisher: Springer Science & Business Media
ISBN: 9400738587
Size: 23.32 MB
Format: PDF
Category : Medical
Languages : en
Pages : 572
View: 5371

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Computational neurosciences and systems biology are among the main domains of life science research where mathematical modeling made a difference. This book introduces the many different types of computational studies one can develop to study neuronal systems. It is aimed at undergraduate students starting their research in computational neurobiology or more senior researchers who would like, or need, to move towards computational approaches. Based on their specific project, the readers would then move to one of the more specialized excellent textbooks available in the field. The first part of the book deals with molecular systems biology. Functional genomics is introduced through examples of transcriptomics and proteomics studies of neurobiological interest. Quantitative modelling of biochemical systems is presented in homogeneous compartments and using spatial descriptions. A second part deals with the various approaches to model single neuron physiology, and naturally moves to neuronal networks. A division is focused on the development of neurons and neuronal systems and the book closes on a series of methodological chapters. From the molecules to the organ, thinking at the level of systems is transforming biology and its impact on society. This book will help the reader to hop on the train directly in the tank engine.

23 Problems In Systems Neuroscience

23 Problems in Systems Neuroscience PDF
Author: J. Leo van Hemmen
Publisher: Oxford University Press on Demand
ISBN: 0195148223
Size: 19.73 MB
Format: PDF, Mobi
Category : Medical
Languages : en
Pages : 514
View: 4707

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The complexity of the brain and the protean nature of behavior remain the most elusive area of science, but also the most important. van Hemmen and Sejnowski invited 23 experts from the many areas--from evolution to qualia--of systems neuroscience to formulate one problem each. Although each chapter was written independently and can be read separately, together they provide a useful roadmap to the field of systems neuroscience and will serve as a source of inspirations for future explorers of the brain.

Grundlagen Zur Neuroinformatik Und Neurobiologie

Grundlagen zur Neuroinformatik und Neurobiologie PDF
Author: Patricia S. Churchland
Publisher: Springer-Verlag
ISBN: 3322868214
Size: 59.39 MB
Format: PDF, Mobi
Category : Technology & Engineering
Languages : de
Pages : 702
View: 1849

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The Computational Brain, das außergewöhnliche Buch über vergleichende Forschung in den Bereichen von menschlichem Gehirn und neuesten Möglichkeiten der Computertechnologie, liegt hiermit erstmals in deutscher Sprache vor. Geschrieben von einem führenden Forscherteam in den USA, ist es eine Fundgrube für alle, die wissen wollen, was der Stand der Wissenschaft auf diesem Gebiet ist. Die Autoren führen die Bereiche der Neuroinformatik und Neurobiologie mit gut ausgesuchten Beispielen und der gebotenen Hintergrundinformation gekonnt zusammen. Das Buch wird somit nicht nur dem Fachwissenschaftler sondern auch dem interdisziplinären Interesse des Informatikers und des Biologen auf eine hervorragende Weise gerecht. Übersetzt wurde das Buch von Prof. Dr. Steffen Hölldobler und Dipl.-Biol. Claudia Hölldobler, einem Informatiker und einer Biologin. Rezension in Spektrum der Wissenschaft nr. 10, S. 122 f. im Oktober 1997 (...) Die 1992 erschienene amerikanische Originalausgabe des vorliegenden Werkes ist so erfolgreich, daß man bereits von einem Klassiker reden kann. (...) (...) ....ist das Buch sehr zu empfehlen. In Verbindung von Neurobiologie und Neuroinformatik konkurrenzlos, vermittelt es einiges von der Faszination theoretischer Hirnforschung, die auch in Deutschland zunehmend mehr Wissenschaftler in ihren Bann schlägt. Rezension erschienen in: Computer Spektrum 3/1997, S. 2 (...)Das Buch wird somit nicht nur dem Fachwissenschaftler, sondern auch den interdisziplinären Interesse des Informatikers und des Biologen auf eine hervorragende Weise gerecht(...)

Computational Neuroscience Trends In Research 1999

Computational Neuroscience  Trends in Research 1999 PDF
Author: J.M. Bower
Publisher: Elsevier
ISBN: 9780444503077
Size: 15.21 MB
Format: PDF, Docs
Category : Medical
Languages : en
Pages : 1090
View: 558

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This volume includes papers originally presented at the 7th annual Computational Neuroscience Meeting (CNS'98) held in July of 1998 at the Fess Parker Doubletree Inn in Santa Barbara, California. The CNS meetings bring together computational neuroscientists representing many different fields and backgrounds as well as many different experimental preparations and theoretical approaches. The papers published here range from pure experimental neurobiology, to neuro-ethology, mathematics, physics, and engineering. In all cases the research described is focused on understanding how nervous systems compute. The actual subjects of the research include a highly diverse number of preparations, modeling approaches, and analysis techniques. Accordingly, this volume reflects the breadth and depth of current research in computational neuroscience taking place throughout the world.

Principles Of Computational Modelling In Neuroscience

Principles of Computational Modelling in Neuroscience PDF
Author: David Sterratt
Publisher: Cambridge University Press
ISBN: 1139500791
Size: 54.30 MB
Format: PDF, Kindle
Category : Medical
Languages : en
Pages :
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The nervous system is made up of a large number of interacting elements. To understand how such a complex system functions requires the construction and analysis of computational models at many different levels. This book provides a step-by-step account of how to model the neuron and neural circuitry to understand the nervous system at all levels, from ion channels to networks. Starting with a simple model of the neuron as an electrical circuit, gradually more details are added to include the effects of neuronal morphology, synapses, ion channels and intracellular signalling. The principle of abstraction is explained through chapters on simplifying models, and how simplified models can be used in networks. This theme is continued in a final chapter on modelling the development of the nervous system. Requiring an elementary background in neuroscience and some high school mathematics, this textbook is an ideal basis for a course on computational neuroscience.

Computational Models Of Brain And Behavior

Computational Models of Brain and Behavior PDF
Author: Ahmed A. Moustafa
Publisher: John Wiley & Sons
ISBN: 1119159067
Size: 21.69 MB
Format: PDF, ePub, Mobi
Category : Psychology
Languages : en
Pages : 584
View: 1199

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A comprehensive Introduction to the world of brain and behavior computational models This book provides a broad collection of articles covering different aspects of computational modeling efforts in psychology and neuroscience. Specifically, it discusses models that span different brain regions (hippocampus, amygdala, basal ganglia, visual cortex), different species (humans, rats, fruit flies), and different modeling methods (neural network, Bayesian, reinforcement learning, data fitting, and Hodgkin-Huxley models, among others). Computational Models of Brain and Behavior is divided into four sections: (a) Models of brain disorders; (b) Neural models of behavioral processes; (c) Models of neural processes, brain regions and neurotransmitters, and (d) Neural modeling approaches. It provides in-depth coverage of models of psychiatric disorders, including depression, posttraumatic stress disorder (PTSD), schizophrenia, and dyslexia; models of neurological disorders, including Alzheimer’s disease, Parkinson’s disease, and epilepsy; early sensory and perceptual processes; models of olfaction; higher/systems level models and low-level models; Pavlovian and instrumental conditioning; linking information theory to neurobiology; and more. Covers computational approximations to intellectual disability in down syndrome Discusses computational models of pharmacological and immunological treatment in Alzheimer's disease Examines neural circuit models of serotonergic system (from microcircuits to cognition) Educates on information theory, memory, prediction, and timing in associative learning Computational Models of Brain and Behavior is written for advanced undergraduate, Master's and PhD-level students—as well as researchers involved in computational neuroscience modeling research.

Systems Medicine

Systems Medicine PDF
Author:
Publisher: Academic Press
ISBN: 0128160780
Size: 26.26 MB
Format: PDF, Mobi
Category : Science
Languages : en
Pages : 1589
View: 7043

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Technological advances in generated molecular and cell biological data are transforming biomedical research. Sequencing, multi-omics and imaging technologies are likely to have deep impact on the future of medical practice. In parallel to technological developments, methodologies to gather, integrate, visualize and analyze heterogeneous and large-scale data sets are needed to develop new approaches for diagnosis, prognosis and therapy. Systems Medicine: Integrative, Qualitative and Computational Approaches is an innovative, interdisciplinary and integrative approach that extends the concept of systems biology and the unprecedented insights that computational methods and mathematical modeling offer of the interactions and network behavior of complex biological systems, to novel clinically relevant applications for the design of more successful prognostic, diagnostic and therapeutic approaches. This 3 volume work features 132 entries from renowned experts in the fields and covers the tools, methods, algorithms and data analysis workflows used for integrating and analyzing multi-dimensional data routinely generated in clinical settings with the aim of providing medical practitioners with robust clinical decision support systems. Importantly the work delves into the applications of systems medicine in areas such as tumor systems biology, metabolic and cardiovascular diseases as well as immunology and infectious diseases amongst others. This is a fundamental resource for biomedical students and researchers as well as medical practitioners who need to need to adopt advances in computational tools and methods into the clinical practice. Encyclopedic coverage: ‘one-stop’ resource for access to information written by world-leading scholars in the field of Systems Biology and Systems Medicine, with easy cross-referencing of related articles to promote understanding and further research Authoritative: the whole work is authored and edited by recognized experts in the field, with a range of different expertise, ensuring a high quality standard Digitally innovative: Hyperlinked references and further readings, cross-references and diagrams/images will allow readers to easily navigate a wealth of information

Systems Biology

Systems Biology PDF
Author: Marvin Cassman
Publisher: Springer Science & Business Media
ISBN: 1402054688
Size: 79.86 MB
Format: PDF, Kindle
Category : Mathematics
Languages : en
Pages : 262
View: 6808

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This book explores Systems Biology as the understanding of biological network behaviors, and in particular their dynamic aspects, which requires the utilization of mathematical modeling tightly linked to experiment. A variety of approaches are discussed here: the identification and validation of networks, the creation of appropriate datasets, the development of tools for data acquisition and software development, and the use of modeling and simulation software in close concert with experiment.

Invitation To Generalized Empirical Method In Philosophy And Science

Invitation To Generalized Empirical Method  In Philosophy And Science PDF
Author: Quinn Terrance J
Publisher: World Scientific
ISBN: 9813208457
Size: 55.99 MB
Format: PDF, Docs
Category : Science
Languages : en
Pages : 228
View: 6513

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Bernard Lonergan identified the need and possibility of what he called "generalized empirical method" in science and philosophy. Implementation will be a future community achievement. The book enters into details of a selection of examples in the sciences and philosophy of science. These are provided not to engage in, or blend the present aim with traditional philosophical debate, but as points of entry to help reveal the possibility and need of balanced empirical method. Taking words of Lonergan: "(Q)uestions of method are practical. So my purpose in these (chapters) is not to demonstrate what is necessary. It is not to forecast what is probable. It is ... to invite you to share in the exploration of a proposal" (Bernard Lonergan, A Third Collection (1985), 114). The main examples are drawn from biochemistry and biology, although heuristics envisioned will include all sciences.

Stadtverkehrsplanung

Stadtverkehrsplanung PDF
Author: Gerd Steierwald
Publisher: Springer-Verlag
ISBN: 3540270108
Size: 78.16 MB
Format: PDF, ePub, Docs
Category : Technology & Engineering
Languages : de
Pages : 829
View: 5356

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Das in der Fachwelt als Standardwerk eingeschätzte Buch behandelt die Probleme und Lösungsansätze der modernen Stadtverkehrsplanung. Ausgehend von der Einbindung der Verkehrsplanung in die Stadtplanung wird dem Leser eine grundlegende Darstellung zu den Methoden und Verfahren dieses weiten Fachgebietes vermittelt. Die als Hochschullehrer und Praktiker anerkannten Autoren behandeln die Grundlagen und Ziele der Planung, die Analyse und Prognose der Verkehrsentwicklung – insbesondere der Modellierung – und liefern nach den heutigen Erkenntnissen eine umfassende Übersicht über den Einfluss des Verkehrs auf alle Bereiche der humanen und natürlichen Umwelt einschließlich der Bewertung. Weitere Schwerpunkte bilden die Gestaltung und der Entwurf städtischer Verkehrsanlagen, bei denen der öffentliche Raum in der Stadt, die Straßen- und die Knotenpunkte, der ruhende Verkehr und die Anlagen des öffentlichen Verkehrs behandelt werden. Die neue Auflage wurde nicht nur gründlich bearbeitet und erneuert, sondern bringt zusätzliche Kapitel über Verkehrsleitbilder im Städtebau, Wirtschafts- und Güterverkehr, zur Leistungsfähigkeit von Verkehrsanlagen, zum Fußgänger- und Radverkehr, zu Verkehrsmanagement, Lichtsignalsteuerung, Technikfolgenabschätzung, Road Pricing und Planungsrecht. Die Darstellungen bieten dem Stadt- und Verkehrsplaner sowie Studierenden des Verkehrs- und Stadtbauwesens ein umfassendes Instrumentarium zur Lösung der gegenwärtigen Aufgaben, unter Berücksichtigung der wesentlichen Empfehlungen und Richtlinien.

Emergent Neural Computational Architectures Based On Neuroscience

Emergent Neural Computational Architectures Based on Neuroscience PDF
Author: Stefan Wermter
Publisher: Springer Science & Business Media
ISBN: 9783540423638
Size: 17.68 MB
Format: PDF
Category : Computers
Languages : en
Pages : 576
View: 5414

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It is generally understood that the present approachs to computing do not have the performance, flexibility, and reliability of biological information processing systems. Although there is a comprehensive body of knowledge regarding how information processing occurs in the brain and central nervous system this has had little impact on mainstream computing so far. This book presents a broad spectrum of current research into biologically inspired computational systems and thus contributes towards developing new computational approaches based on neuroscience. The 39 revised full papers by leading researchers were carefully selected and reviewed for inclusion in this anthology. Besides an introductory overview by the volume editors, the book offers topical parts on modular organization and robustness, timing and synchronization, and learning and memory storage.

An Introduction To Neural Information Processing

An Introduction to Neural Information Processing PDF
Author: Peiji Liang
Publisher: Springer
ISBN: 9401773939
Size: 34.83 MB
Format: PDF, Kindle
Category : Medical
Languages : en
Pages : 328
View: 6118

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This book provides an overview of neural information processing research, which is one of the most important branches of neuroscience today. Neural information processing is an interdisciplinary subject, and the merging interaction between neuroscience and mathematics, physics, as well as information science plays a key role in the development of this field. This book begins with the anatomy of the central nervous system, followed by an introduction to various information processing models at different levels. The authors all have extensive experience in mathematics, physics and biomedical engineering, and have worked in this multidisciplinary area for a number of years. They present classical examples of how the pioneers in this field used theoretical analysis, mathematical modeling and computer simulation to solve neurobiological problems, and share their experiences and lessons learned. The book is intended for researchers and students with a mathematics, physics or informatics background who are interested in brain research and keen to understand the necessary neurobiology and how they can use their specialties to address neurobiological problems. It is also provides inspiration for neuroscience students who are interested in learning how to use mathematics, physics or informatics approaches to solve problems in their field.

Molekulare Virologie

Molekulare Virologie PDF
Author: Susanne Modrow
Publisher: Springer-Verlag
ISBN: 3827422418
Size: 66.54 MB
Format: PDF, ePub, Docs
Category : Science
Languages : de
Pages : 734
View: 5272

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Vom Gen zur Pathogenese Das Lehrbuch Molekulare Virologie, seit vielen Jahren als unentbehrliches Standardwerk für Fachleute und Studenten etabliert, liegt nun wieder in einer überarbeiteten und erweiterten Neuauflage vor. Neben der durchgängigen Aktualisierung der Inhalte und Literaturzitate sind unter anderem Layout und Format des Buches angepasst sowie die eingestreuten Exkurse, die schlaglichtartig interessante Einzelthemen beleuchten, thematisch differenziert worden. Durch Einbindung eines zusätzlichen Autors sind zudem humanmedizinisch-klinische Aspekte nun noch stärker berücksichtigt. Molekulare Virologie ist eine Einführung in die molekular- und zellbiologischen Grundlagen von Virusinfektionen bei Mensch und Tier. Das Buch vermittelt einen ausgewogenen Überblick über humanpathogene und tierpathogene Viren. Mit seiner klaren Gliederung und verständlichen Darstellung weist dieses systematisch angelegte Lehr- und Nachschlagewerk sowohl Studenten und Dozenten der Biologie, Human- und Veterinärmedizin als auch Virologen, forschungsorientierten Klinikern, Tierärzten und Seuchenmedizinern sowie Fachleute in Mikrobiologie, Hygiene und Diagnostik den Weg durch die Vielfalt der virologischen Forschungsergebnisse. Im ersten Teil des Buches arbeiten die Autoren die allgemeinen Prinzipien der Struktur, Vermehrung und Lebenszyklen von Viren heraus und beschreiben die wichtigsten pathogenetischen und immunologischen Mechanismen viraler Erkrankungen. Auch die Diagnostik und Therapie sowie die Epidemiologie solcher Infektionen und das heutige Methodenrepertoire der Virologen werden hier vorgestellt. Der zweite, spezielle Teil führt dann systematisch durch die Vielfalt der human- und tierpathogenen Viren. Ausführlich werden zum einen die Morphologie, die Genomorganisation und die Proteinaustattung sowie die Replikationsmechanismen der verschiedenen Virusfamilien dargestellt. Für die jeweils wichtigsten Vertreter präsentieren die Autoren zum anderen einen Überblick über die relevanten humanmedizinisch-klinischen beziehungsweise veterinärmedizinischen Aspekte. Auch seuchenrechtliche Aspekte kommen hier zur Sprache. Dem Autorenteam gelingt es mit diesem Werk erneut, Virologie in ihrer ganzen Spannbreite - vom Molekül bis zur Klinik - überschaubar zu machen. Mit der konsequenten Verknüpfung dieser beiden Zugänge schlägt dieses Werk zudem dringend benötigte Brücken zwischen (molekular)biologischer Grundlagenforschung und medizinischer Anwendung.

Computational Neuroscience For Advancing Artificial Intelligence Models Methods And Applications

Computational Neuroscience for Advancing Artificial Intelligence  Models  Methods and Applications PDF
Author: Alonso, Eduardo
Publisher: IGI Global
ISBN: 1609600231
Size: 46.70 MB
Format: PDF, ePub, Mobi
Category : Computers
Languages : en
Pages : 396
View: 1826

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"This book argues that computational models in behavioral neuroscience must be taken with caution, and advocates for the study of mathematical models of existing theories as complementary to neuro-psychological models and computational models"--